Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Sigma Aldrich Fine Chemicals Biosciences TRIFLUOROACETIC ACID 100ML
NC3241523 TRIFLUOROACETIC ACID 100ML
eMolecules 76-05-1 | Trifluoroacetic acid, >=99.995% Trace metals grade | Oakwood Chemical | MFCD00004169 | 114.023 | C2HF3O2 | 99.000 | OC(=O)C(F)(F)F | 25g | 537709015
Trifluoroacetic acid, >=99.995% Trace metals grade | Oakwood Chemical | 76-05-1 | MFCD00004169 | 114.023 | C2HF3O2 | 99.000 | OC(=O)C(F)(F)F | 25g | 537709015
eMolecules 76-05-1 | Trifluoroacetic acid, >=99.995% Trace metals grade | Oakwood Chemical | MFCD00004169 | 114.023 | C2HF3O2 | 99.000 | OC(=O)C(F)(F)F | 100g | 537709016
Trifluoroacetic acid, >=99.995% Trace metals grade | Oakwood Chemical | 76-05-1 | MFCD00004169 | 114.023 | C2HF3O2 | 99.000 | OC(=O)C(F)(F)F | 100g | 537709016
eMolecules 76-05-1 | Trifluoroacetic acid, >=99.995% Trace metals grade | Oakwood Chemical | MFCD00004169 | 114.023 | C2HF3O2 | 99.000 | OC(=O)C(F)(F)F | 10g | 537709014
Trifluoroacetic acid, >=99.995% Trace metals grade | Oakwood Chemical | 76-05-1 | MFCD00004169 | 114.023 | C2HF3O2 | 99.000 | OC(=O)C(F)(F)F | 10g | 537709014
Chem-Impex International, Inc. Trifluoroacetic acid | 76-05-1 | MFCD00004169 | 100G
Trifluoroacetic acid, 76-05-1, MFCD00004169, 100G
Medchemexpress LLC Cys-TAT(47-57) TFA | 98.1% | 1661.99 | 5 MG
Cys-TAT(47-57) (Cys-[HIV-Tat (47-57)]) is an arginine rich cell penetrating peptide derived from the HIV-1 transactivating protein.
- Appearance: Solid
- Color: White to off-white
- Sequence: Cys-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-NH2
- Shipping: Room temperature in continental US
- Storage (powder): -80°C for 2 years, -20°C for 1 year (sealed, away from moisture and light, under nitrogen)
- Storage (in solvent): -80°C for 6 months, -20°C for 1 month (sealed, away from moisture and light, under nitrogen)
- Solubility (H2O): 100 mg/mL (needs ultrasonic)
- Solubility (DMSO): ≥ 100 mg/mL
- Related classifications: Peptides, Peptide and derivatives, Peptides for drug delivery, Cell-penetrating peptides
- Disease areas: Infection, Anti-infection HIV
Medchemexpress LLC Maurocalcine (TFA) | 95.1% | 3858.55 (free base) | 100 UG
Maurocalcine TFA is an agonist of ryanodine receptor (RyR) channel types 1, 2 and 3 with cellular permeability. It induces [3H]ryanodine binding on RyR1 with an EC50 value of 2558 nM. This product exhibits an apparent affinity of 14 nM for RyR2 and can be applied to in vivo cell tracking or other cell imaging techniques.
- Agonist of ryanodine receptor (RyR) channel types 1, 2 and 3
- Exhibits cellular permeability
- Induces [3H]ryanodine binding on RyR1 with an EC50 value of 2558 nM
- Exhibits an apparent affinity of 14 nM for RyR2
- Can be applied to in vivo cell tracking or other cell imaging techniques
Medchemexpress LLC Box5 (TFA) | 00-00-0 | 99.2% | 880.9 Da | C32H51F3N6O15S2.xC2HF3O2 | 5 MG
Box5 TFA is the trifluoroacetate salt form of a peptide antagonist of Wnt5a used in vitro to study Wnt5a-mediated signaling, calcium release, and cell migration. Supplied in small milligram vials, the material is provided with documentation to support research use.
- Trifluoroacetate salt form for improved solubility and handling.
- Potent antagonist of Wnt5a signaling for pathway studies.
- Inhibits Wnt5a-mediated calcium release and cell migration.
- High purity approximately 99.2% for consistent results.
- Supplied in small milligram sizes suitable for in vitro experiments.
- COA and SDS available for quality and safety verification.
Medchemexpress LLC MM-102 trifluoroacetate | 1883545-52-5 | 99.7% | 2 MG
MM-102 TFA is the trifluoroacetate salt of MM-102, a research reagent that inhibits the WDR5/MLL protein-protein interaction. It is supplied as high-purity solid and as DMSO solution formats for biochemical and cellular studies, with reported potency in WDR5 binding assays.
- Potent inhibitor of the WDR5/MLL protein-protein interaction.
- Reported IC50 = 2.4 nM in WDR5 binding assay.
- High reported purity (99.68%).
- Available in small solid quantities and as 10 mM in DMSO solution.
- Trifluoroacetate salt form for convenient handling and solubility.
